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Intro

So most of these peptides are injected.  If we look back on supplements, most of them don't do anything, yet a few ended up important (vit-D3). There was a move to regulate supplimnets off the market. Most of these peptides are natural bits that are found in our bodies - thus not patentable - thus pharma has no interest except to ban.

Peptide Notes

5-amino-1mq

Reduced fat in rodents - might protect nad ?? 

Adipotide

Kills fat cells - need a lot more data.

AOD-9604

Re loss of visceral fat - the evidence for AOD-9604 in humans is inconsistent and not specific to lean individuals. Didn't work ..

ARA-290 (cibinetide)

Might help with neuopathy..

BPC-157 (14,195Da)

Body Protection Compound.  Not good human data. 

CJC1295

ups IGF-1 levels.

DAC

Dihexa not true peptide

Might help with brain - science fraud --- no good studies.
GHK-Cu (403 Da)
healing joints peptide

DSIP

Might improve delta sleep.

Epithalon

Longevity.  Might lengthen telemere  - almost no data.  Most of what is sold is fake.

GHK-Cu

Sold topically for a long time.  Injected? - Almost no data.

GHRP-2 & GHRP-6

Boosts GH

HCG

Not a peptide. Restores libido.

IGF-1

Human growth hormone. Very short half life

IGF1-LR3

Long release form of  IGF-1

Insulin

Ipamorelin

GH Secretagogue? Some data - does it work well enough?

Kisspeptin

Ups GNRH release.

KPV

unique anti-inflammatory mechanisms (NF-kB & MAPK inhibition),  Zero human studies.

NAD+

Might be total BS - oral might just get converted to a B vitamin?

NVG-291

Mazdutide

GLP-1 drug. New drug.

Melanotan-1 Melanotan-2 (PT-141)

MTP-131

MT drug -


MOTS-c

  supposed to burn fat while not reducing muscle. Does something similar to exercising?
Might help with neuropathy?  Protocol 5-15 mg 3x/week for 2-3 mo - then 1-2 months off?

Pep19

 In a small 60-day study, obese adults (BMI 30-35) taking 5mg of Pep19 saw a 17% reduction in visceral fat without losing lean muscle mass

J-147

Might help - synthetic curcumin?


Retatrutide

triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors)

Reta

Selank

Might help sleep -

Semax

Fuzzy data. might help cognition..


Samoralin

Growth hormone secretagogue.  Better sleep. 

Selank

Semax is a synthetic derivative of adrenocorticotropic hormone. The Ministry of Health and Pharmaceutical Industry of the Russian Federation approved the clinical use of Semax on March 28, 1996. It is a neuroactive peptide with endogenous regulatory properties that affects brain cellular processes, helping to protect and enhance ischemic injury (e.g., stroke, closed head injury), neurodegenerative processes (e.g., Alzheimer's disease) Brain function recovery after Alzheimer's disease, Parkinson's disease, and Huntington's disease. It is mainly used in Russia to treat various diseases and is included in the Russian list of important and essential medicines.
 
Semax powder is the basis ingredient for many pharmacological products in the United States and is also used in clinical practice to treat various neurological disorders. Healthy individuals pursuing extreme sports and higher fitness goals use them to enhance performance and fitness.
 
Often referred to as a “nootropic,” Semax has been shown to improve cognitive function and memory. Some people use it to increase productivity and concentration, while others use it to improve learning and problem-solving skills. In addition to this, Semax may also be used to treat various brain disorders such as stroke, traumatic brain injury, and cardiovascular disease.

Semaglutide (4000+Da)

 Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism

Typical dosage 0.25mg/weekly for first 4 weeks - increasing to .5mg - for next 4 weeks - then 1mg.

Most people would do well to lose weight SLOWLY -

SLU-PP-332

Small molecule - not true peptide.  Exercise mimemetic?  Animal data only..

SP16

LRP1 Agonist . Preclinical studies show it stimulates nerve fiber growth even in the presence of neurotoxic chemotherapy

SS-31 (640 da)

Mitochondria repair - new energy? Heads to MT. Cardiolipin fix.  Mixed science - failed human studies, but over specific endpoints? Provisional approval for Barth syndrome. Might take long term exposure? Trials had 40mg/day.  Appears to have good safety profile.

TB-500

Might help wound repair (see wolverine stack). Lack of human data.

Tesamorelin

Might help with visceral fat.  GH release?  Very expensive -

https://pubmed.ncbi.nlm.nih.gov/18057338/#abstract%23
skypeptides


Tirzepatide

GLP and GIP agonist -  Dual GLP-1 drug


Natural ways to Boost GLP-1

GLP-1 Reduces inflammation



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